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Although initial reports have suggested that pulmonary vasodilators may have led to harm in patients with LV dysfunction and PH, more recent studies in patients with a persistently elevated transpulmonary gradient despite medically optimized LV function or mechanical support have shown benefit from pulmonary vasodilators such as sildenafil .
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Left ventricular hypertrophy (LVH) means that the muscle of the heart's main pump (left ventricle) has become thick and enlarged. This can happen over time if the left ventricle has to work too hard. This part of the heart needs to be strong to pump oxygen-rich blood to your entire body.
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